UniProt data
UniProt name: APRIO_HUMAN (F7VJQ1)
Gene name: PRNP; Synonyms=ALTPRP, PRIP, PRP
Organism: Homo sapiens (Human).
Function:
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:21478263}; Single-pass membrane protein {ECO:0000269|PubMed:21478263}.
Transmembrane domains:
- 32-52, 21 AA, Helical. {ECO:0000255}.
Sequence: 73 AA
CATM prediction
The sequence of APRIO_HUMAN returned 2 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 30 40 50 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | AASWWWLGAASWWWLGAAAWWWLGTAS | 7.2 | -51.0° | 2.4 | 44.7 | -15.4 |
| Model 2 | AASWWWLGAASWWWLGAAAWWWLGTAS | 6.8 | -55.0° | 1.5 | 44.9 | -15.0 |
| Prolines* | AASWWWLGAASWWWLGAAPWWWLGTAS |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 33, TRP, HA | A, 32, TRP, O | 3.25Å |
| B, 36, GLY, HA1 | A, 33, TRP, O | 2.88Å |
| B, 37, ALA, HA | A, 36, GLY, O | 3.31Å |
| B, 33, TRP, HE1 | A, 39, SER, OG | 2.06Å |
| A, 33, TRP, HA | B, 32, TRP, O | 3.25Å |
| A, 36, GLY, HA1 | B, 33, TRP, O | 2.88Å |
| A, 37, ALA, HA | B, 36, GLY, O | 3.31Å |
| A, 33, TRP, HE1 | B, 39, SER, OG | 2.06Å |
