Mucin-22

UniProt data

UniProt name: MUC22_HUMAN (E2RYF6)

Gene name: MUC22; Synonyms=G4, PBMUCL1

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1661-1681, 21 AA, Helical. {ECO:0000255}.

Sequence: 1773 AA

10 20 30 40 50 60 MRRGNISPAF WFLWLLLFGL LGPSSENTTA FTKGSDTTTA SITGSETTMA STMASTSALT 70 80 90 100 110 120 TGSKITTDST TGSETTSAST MASTAAFTTG SETNTASTTD SGTTIASTRT FTTGSDTTTG 130 140 150 160 170 180 STAGSETIVA STTVSGTTTT FTIASTTVPE TTMASSTTST AGSEKTMASS IISETTMAST 190 200 210 220 230 240 TGSETATVST TGSETTTTST ASSEATKVST TGSETTTAST AGSETTTTST SMAGSEATTT 250 260 270 280 290 300 STADSKVITA SSMSSETTVA PAAGSNTTTA STTGSETTTI LIKASETTTA STAGSETTTP 310 320 330 340 350 360 SPTGSQTTIV SISGSEITTT STAGSENTTV SSAGSGTTTA SMAGSETTVS TAGSETTTVS 370 380 390 400 410 420 ITGTETTMVS AMGSETTTNS TTSSETTVTS TAGSETTTVS TVGSETTTAY TADSETTAAS 430 440 450 460 470 480 TTGSEMTTVF TAGSETITPS TAGSETTTVS TAGSETTTVS TTGSETTTAS TAHSETTAAS 490 500 510 520 530 540 TMGSETTKVS TAGSETTVST AGSETTAAST EDSETNTAFT EDSKTTTAST TGFETTAAST 550 560 570 580 590 600 TGSEPTMAST MGSETTMAST IGPETTKVST ASSEVTTVFA AGSETIRAST VGSETTTVST 610 620 630 640 650 660 TGSETTTASI MGSETSTDST TGSETTTAST EGSETTTAST EGSEATTVST TGSETTTVSI 670 680 690 700 710 720 TDSETTTTCT EGSEMTAVST TVFETTTAST EGSEITIAST SDSETTTAST EGSETTTVTT 730 740 750 760 770 780 AGSETKTAYT TGSETTTASN TGLETTTVFT IGSDTTTAST EGSETTAVSA TGSEMTTVST 790 800 810 820 830 840 EGSENTTVST TGSETTTVST TGLETTTTST EGSEMTTVST TGAETTTDST EGSGTTAAST 850 860 870 880 890 900 AGSETTTVST ADSENTTAST ADSETTSAST TGSETTTAST TSSETTTAST EGSETTTVST 910 920 930 940 950 960 TDSETTMVST TGSERTITST EGSETTTVSA TGSETTVSTE GSGTTTVSIT GSETTKVSTT 970 980 990 1000 1010 1020 GSETTTTSTE GSEITTASIT GSETTTASTE GSETTTASTE GSETTSASTT GSETTTASTT 1030 1040 1050 1060 1070 1080 SSETTMASIM GSETTMASTI GSETTKVSTA SSKMTTVFTE NSETTIASTT ASETTTVSTA 1090 1100 1110 1120 1130 1140 GSETIPASTA GSETTTTTST EGSETTTAST EGSETTTAST ESSETTTATT IGSETTTAST 1150 1160 1170 1180 1190 1200 EGSETTTTST EGSETTTAST EGSEITTVST TGSETTTAST EGSETTTAST EGSELTTVST 1210 1220 1230 1240 1250 1260 TGSETITVSA EGSETTTVTT MGSETTTAST AGSETTTVST AGSETTTASI EGSETTTVSS 1270 1280 1290 1300 1310 1320 TGSETTTVST TGTETTITST EGSETTTVTT AGSETTAVYT TGSETTTTST EGSETTTVST 1330 1340 1350 1360 1370 1380 TGSETTTAST ADLETTTVST SGSGTTTAST AGSETTTVYI TGSKTTTAST EGSEATTVST 1390 1400 1410 1420 1430 1440 TSSETTTAST TGSEMTTVFT TVSETTTVST IGSEATTSSA AGSEATTTST EGSETTTAST 1450 1460 1470 1480 1490 1500 AGSETTTAST AGSETTTAST SGSETNTACT TGSETSTPSS AGSETNTAFI IGSESTIAST 1510 1520 1530 1540 1550 1560 ASLEPTATSL TGSETTTVSI TASGATAAST TVSSTTFVLT KATDVSIQPI TNTPMSGTRT 1570 1580 1590 1600 1610 1620 TGTRLTASSS VTMAPGMDFT ASAASHTVPG IVLNTSGLGT STMGASSTTS AHGVRTTTGS 1630 1640 1650 1660 1670 1680 TREPTSSTFQ ETGPVSMGTN TVSMSHTPTN VIKPSGYLQP WAIILISLAA VVAAVGLSVG 1690 1700 1710 1720 1730 1740 LSFCLRNLFF PLRYCGIYYP HGHSHSLGLD LNLGLGSGTF HSLGNALVHG GELEMGHGGT 1750 1760 1770 HGFGYGVGHG LSHIHGDGYG VNHGGHYGHG GGH

CATM prediction

The sequence of MUC22_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    1660      1670      1680 
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 LQAWAIILISLAAVVAAVGLSVGLSFC 6.7 -44.2° 0.9 46.0 -31.6
Prolines* LQPWAIILISLAAVVAAVGLSVGLSFC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1673, ALA, HA A, 1672, VAL, O 3.15Å
B, 1676, GLY, HA1 A, 1673, ALA, O 2.76Å
B, 1677, LEU, HA A, 1676, GLY, O 2.79Å
A, 1673, ALA, HA B, 1672, VAL, O 3.15Å
A, 1676, GLY, HA1 B, 1673, ALA, O 2.76Å
A, 1677, LEU, HA B, 1676, GLY, O 2.79Å