Sialic acid-binding Ig-like lectin 16

UniProt data

UniProt name: SIG16_HUMAN (A6NMB1)

Gene name: SIGLEC16; Synonyms=SIGLECP16

Organism: Homo sapiens (Human).

Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000269|PubMed:18629938}; Single-pass type I membrane protein {ECO:0000269|PubMed:18629938}.

Transmembrane domains:

  1. 435-455, 21 AA, Helical. {ECO:0000255}.

Sequence: 481 AA

10 20 30 40 50 60 MLLLPLLLPV LGAGSLNKDP SYSLQVQRQV PVPEGLCVIV SCNLSYPRDG WDESTAAYGY 70 80 90 100 110 120 WFKGRTSPKT GAPVATNNQS REVAMSTRDR FQLTGDPGKG SCSLVIRDAQ REDEAWYFFR 130 140 150 160 170 180 VERGSRVRHS FLSNAFFLKV TALTQKPDVY IPETLEPGQP VTVICVFNWA FKKCPAPSFS 190 200 210 220 230 240 WTGAALSPRR TRPSTSHFSV LSFTPSPQDH DTDLTCHVDF SRKGVSAQRT VRLRVASLEL 250 260 270 280 290 300 QGNVIYLEVQ KGQFLRLLCA ADSQPPATLS WVLQDRVLSS SHPWGPRTLG LELPGVKAGD 310 320 330 340 350 360 SGRYTCRAEN RLGSQQRALD LSVQYPPENL RVMVSQANRT VLENLRNGTS LRVLEGQSLR 370 380 390 400 410 420 LVCVTHSSPP ARLSWTWGEQ TVGPSQPSDP GVLQLPRVQM EHEGEFTCHA RHPLGSQRVS 430 440 450 460 470 480 LSFSVHCKSG PMTGVVLVAV GEVAMKILLL CLCLILLRVR SCRRKAARAA LGMEAADAVT D

CATM prediction

The sequence of SIG16_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          440       450      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 MTGVVLVAVGEVAMKILLLCLCLILLR 7.3 -51.1° 2.4 44.9 -23.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 438, VAL, HA A, 437, LEU, O 3.37Å
B, 441, GLY, HA1 A, 438, VAL, O 3.14Å
A, 438, VAL, HA B, 437, LEU, O 3.37Å
A, 441, GLY, HA1 B, 438, VAL, O 3.14Å