UniProt data
UniProt name: LRC53_HUMAN (A6NM62)
Gene name: LRRC53
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Transmembrane domains:
- 294-314, 21 AA, Helical. {ECO:0000255}.
Sequence: 1247 AA
10 20 30 40 50 60
MLRLVAACPE SCVVCTKDVT LCHQLTYIVA APMTTRVLII TDGYLSSIES TNLSLLFNLA
70 80 90 100 110 120
LLSLSRNGIE DVQEDALHGL TMLRTLLLEH NQISSSSLTD HTFSKLHSLQ VLVLSNNALR
130 140 150 160 170 180
TLRGSWFRNT SGLTRLQLDG NQITNLTDSS FGGTNLHSLR YLDLSNNFIS YIGKDAFRPL
190 200 210 220 230 240
PQLQEVDLSR NRLAHMPDVF TPLKQLILLS LDKNQWSCTC DLHPLARFLR NYIKSSAHTL
250 260 270 280 290 300
RNAKDLNCQP STAAVAAAQS VLRLSETNCD SKAPNFTLVL KDRSPLLPGP DVALLTVLGF
310 320 330 340 350 360
AGAVGLTCLG LVVFNWKLHQ GKANEHTSEN LCCRTFDEPL CAHEARNYHT KGYCNCHLTQ
370 380 390 400 410 420
ENEIKVMSTV GSRKEMPLLQ ENSHQATSAS ESATLDGSFR NLKKKDRGVG STLFCQDGRL
430 440 450 460 470 480
LHSECSEPPG NMRAFNEAGL LTTYNPRKVQ KLWNLEPGEV QPQTLQHHII RTEDISSDIF
490 500 510 520 530 540
RRRYATPASA LAGESLEKRL TNESWQPPIE KEDNGLHPHR QRHFITSSSS KPCEPEEHYV
550 560 570 580 590 600
QKIVQKNRSK YDDPCGLLKQ SKPRYFQPNN SLICKYVPCE QFEDYMKEKK PNRRQHSKPE
610 620 630 640 650 660
KEQIQINSAI EKFLMSEDNI DLSGLSTKTK KAYSPKRVIF HDPDLVEINR SMMSPKISTP
670 680 690 700 710 720
WKRQKNQSNQ LTKLDVKKFS NTGERNKGEK WFTNSWVLKR KRTPQSDLKG KIKGQNLKLN
730 740 750 760 770 780
LHPFRKVRVH PEKSLSSLPK QCKQVLLPPK KLSKTSETEA KINTVCSADF LQQSESSNYV
790 800 810 820 830 840
RLTSKRLPLK HDSKQTPYYQ RNTKRAPLLS ANNLRVVNQS SIESSCYSAG HIPDGNTSKL
850 860 870 880 890 900
PQPTPTDAEH RHSHSQFSTE QMEDATQLES KVLSYLATTW ENTGSDVLPF QHSRRATDQG
910 920 930 940 950 960
TTESTEHMGQ NVSKTSELNQ FSLSPRNQTQ LLDAHKTDSY NKEYTLDQNE ALQHREQNSS
970 980 990 1000 1010 1020
HAQLENKEKT LMTKPQISHQ IVENCIMDKE ENDVEKKLSK TETYDSSLIP QTQSKNNLSF
1030 1040 1050 1060 1070 1080
MKTNSIPYQN RIELPKDIST SPVSSQAVWH LTNSSEKGID STNALPRNDG TEALEIKIVG
1090 1100 1110 1120 1130 1140
KEEKNMLDES KTDSSMLTQI SQMTLKGITK ERQQTWENGT SEKYILHDAS SAEETITAKD
1150 1160 1170 1180 1190 1200
LSITSSHETQ NRILCSEVDP EVNSNVHNFR EVQNIQPDKD SAHKEGAMTV ETHEALSFLP
1210 1220 1230 1240
GLKDSFEAEN EVFLVPSRIN EAENSAPKPV LYPPSAEYAT TSPLETE
CATM prediction
The sequence of LRC53_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 300 310 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | DVALLTVLGFAGAVGLTCLGLVVFNWK | 7.4 | -41.0° | 0.6 | 43.3 | -5.4 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 299, GLY, HA1 | A, 296, THR, O | 3.47Å |
| B, 300, PHE, HA | A, 299, GLY, O | 3.37Å |
| A, 299, GLY, HA1 | B, 296, THR, O | 3.47Å |
| A, 300, PHE, HA | B, 299, GLY, O | 3.37Å |