Protein shisa-7

UniProt data

UniProt name: SHSA7_HUMAN (A6NL88)

Gene name: SHISA7

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 187-207, 21 AA, Helical. {ECO:0000255}.

Sequence: 538 AA

10 20 30 40 50 60 MPALLLLVLL ASSAGQARAR PSNATSAEPA GPLPALLAHL RRLTGALTGG GGAASPGANG 70 80 90 100 110 120 TRTGPAGGAG AAARAPPPAE LCHGYYDVMG QYDATFNCST GSYRFCCGTC HYRFCCEHRH 130 140 150 160 170 180 MRLAQASCSN YDTPRWATTP PPLAGGAGGA GGAGGGPGPG QAGWLEGGRT GGAGGRGGEG 190 200 210 220 230 240 PGGSTAYVVC GVISFALAVG VGAKVAFSKA SRAPRAHRDI NVPRALVDIL RHQAGPGTRP 250 260 270 280 290 300 DRARSSSLTP GIGGPDSMPP RTPKNLYNTV KTPNLDWRAL PPPSPSLHYS TLSCSRSFHN 310 320 330 340 350 360 LSHLPPSYEA AVKSELNRYS SLKRLAEKDL DEAYLKRRPL ELPRGTLPLH ALRRPGTGGG 370 380 390 400 410 420 YRMEAWGGPE ELGLAPAPNP RRVMSQEHLL GDGGRSRYEF TLPRARLVSQ EHLLLSSPEA 430 440 450 460 470 480 LRQSREHLLS PPRSPALPPD PTARASLAAS HSNLLLGPGG PPTPLRGLPP PSSLHAHHHH 490 500 510 520 530 ALHGSPQPAW MSDAGGGGGT LARRPPFQRQ GTLEQLQFIP GHHLPQHLRT ASKNEVTV

CATM prediction

The sequence of SHSA7_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        190       200       2
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 STAYVVCGVISFALAVGVGAKVAFSKA 6.7 -47.1° 1.3 45.1 -18.5
Model 2 STAYVVCGVISFALAVGVGAKVAFSKA 7.4 -49.1° 3.9 38.3 -10.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 199, VAL, HA A, 198, ALA, O 3.02Å
B, 202, GLY, HA1 A, 199, VAL, O 2.62Å
B, 203, ALA, HA A, 202, GLY, O 2.89Å
A, 199, VAL, HA B, 198, ALA, O 3.02Å
A, 202, GLY, HA1 B, 199, VAL, O 2.62Å
A, 203, ALA, HA B, 202, GLY, O 2.89Å