UniProt data
UniProt name: LRIT2_HUMAN (A6NDA9)
Gene name: LRIT2; Synonyms=LRRC22
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 466-486, 21 AA, Helical. {ECO:0000255}.
Sequence: 550 AA
10 20 30 40 50 60
MASVFHYFLL VLVFLDTHAA QPFCLPGCTC SEESFGRTLQ CTSVSLGKIP GNLSEEFKQV
70 80 90 100 110 120
RIENSPLFEM PQGSFINMST LEYLWLNFNN ISVIHLGALE HLPELRELRL EGNKLCSVPW
130 140 150 160 170 180
TAFRATPLLR VLDLKRNKID ALPELALQFL VSLTYLDLSS NRLTVVSKSV FLNWPAYQKC
190 200 210 220 230 240
RQPDCGAEIL SSLVVALHDN PWVCDCRLRG LVQFVKSITL PVILVNSYLI CQGPLSKAGQ
250 260 270 280 290 300
LFHETELSAC MKPQISTPSA NITIRAGQNV TLRCLAQASP SPSIAWTYPL SMWREFDVLT
310 320 330 340 350 360
SSTGEDTALS ELAIPAAHLV DSGNYTCMAS NSIGKSNLVI SLHVQPAQAL HAPDSLSIPS
370 380 390 400 410 420
EGNAYIDLRV VKQTVHGILL EWLAVADTSK EEWFTLYIAS DEAFRKEVVH IGPGINTYAV
430 440 450 460 470 480
DDLLPGTKYE ACLSLEGQPP HQGQCVAFVT GRDAGGLEAR EHLLHVTVVL CVVLLAVPVG
490 500 510 520 530 540
AYAWAAQGPC SCSKWVLRGC LHRRKAPSCT PAAPQSKDGS FREHPAVCDD GEGHIDTEGD
KEKGGTEDNS
CATM prediction
The sequence of LRIT2_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 470 480 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | LLHVTVVLCVVLLAVAVGAYAWAAQGA | 6.9 | -51.2° | 2.4 | 44.4 | -20.9 |
| Prolines* | LLHVTVVLCVVLLAVPVGAYAWAAQGP |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 477, VAL, HA | A, 476, ALA, O | 3.17Å |
| B, 480, GLY, HA1 | A, 477, VAL, O | 2.95Å |
| A, 477, VAL, HA | B, 476, ALA, O | 3.17Å |
| A, 480, GLY, HA1 | B, 477, VAL, O | 2.95Å |