Cadherin-related family member 4

UniProt data

UniProt name: CDHR4_HUMAN (A6H8M9)

Gene name: CDHR4; Synonyms=CDH29; ORFNames=UNQ9392/PRO34300

Organism: Homo sapiens (Human).

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 687-707, 21 AA, Helical. {ECO:0000255}.

Sequence: 788 AA

10 20 30 40 50 60 MVLLRLLVFL FAPVVSDLCS LPCFINVSES QGPGTVLQFL SFNCSSYTPT PTLELLNVQP 70 80 90 100 110 120 PTTFFNPPSL ARWQGTYVGK LTLSSSAQLD ALMVNHYKVQ LKFTCGNHVM EGSLSVDVQR 130 140 150 160 170 180 DLSHIQCAGQ FASPAGEMIQ VPETVTPGAR LYTLLLPGLE LHGAQMSIIS AQDLPHFPGP 190 200 210 220 230 240 FSINEQGWLQ APSQGLLGQA QKVFQLQISV SFGQRQSCQG MVIVKVLPVP SSQVSFLEQA 250 260 270 280 290 300 QNITIPENLA PGSEVVQVQA RGVDLRYEIL SPVPSPLFSI GRADGVVRTT TPLELARTSG 310 320 330 340 350 360 TAVSRLQVKA FEQGQLWASA KLNLTMNVQL VNLWPPRCLP ALLVSQIPET APVGTVLNTL 370 380 390 400 410 420 TCEDPDSVGA TLDYKLWFRS SSNPASLCLY DRVLEVNATL DCDTPGACFQ HAASILVLDG 430 440 450 460 470 480 GQPQMTTEVP VLVMVTPINE FSPACAPRTF RVQEDAAPHT LLGSVVGTDM DYPHDNIEYY 490 500 510 520 530 540 TSGGPTTFAV DRLSGEVHLL GPLDYEQQRL YRLTVLVIDH GQDQNPNHHL SGSCTITIEV 550 560 570 580 590 600 EDVNDHAPEC EPPFQELTIY APLGRSVEVT KMSCQIPQEP QRLIYSYSIV GGNSQNRFIL 610 620 630 640 650 660 QGAILVHSDL VLGPFWPEQP RTYELLICVA DAGPSTPHLS TTATIIVHLV PRRASTVATS 670 680 690 700 710 720 THRTTVPSTM TPMLVTDTEA FWQPQPWFVV VLTATGALLL LALGWLLGRL LQGLAQLLQA 730 740 750 760 770 780 PSKPAQALLL NSIQGTEGSI EGFLEAPKME MSQAPSSVMS LHFDGRAQDS RTGRDYLFNT HTGARRWL

CATM prediction

The sequence of CDHR4_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        690       700       7
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 AQAWFVVVLTATGALLLLALGWLLGRL 7.0 -27.9° 0.0 47.9 -35.7
Model 2 AQAWFVVVLTATGALLLLALGWLLGRL 6.8 -48.3° 0.8 53.9 -33.4
Prolines* PQPWFVVVLTATGALLLLALGWLLGRL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 701, LEU, HA A, 700, LEU, O 3.33Å
B, 704, GLY, HA1 A, 701, LEU, O 3.12Å
B, 705, TRP, HA A, 704, GLY, O 2.80Å
A, 701, LEU, HA B, 700, LEU, O 3.33Å
A, 704, GLY, HA1 B, 701, LEU, O 3.12Å
A, 705, TRP, HA B, 704, GLY, O 2.80Å