Multiple epidermal growth factor-like domains protein 11

UniProt data

UniProt name: MEG11_HUMAN (A6BM72)

Gene name: MEGF11; Synonyms=KIAA1781; ORFNames=UNQ1949/PRO4432

Organism: Homo sapiens (Human).

Function: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:17498693}; Single-pass type I membrane protein {ECO:0000269|PubMed:17498693}. Basolateral cell membrane {ECO:0000269|PubMed:17498693}; Single- pass type I membrane protein {ECO:0000269|PubMed:17498693}. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10.

Transmembrane domains:

  1. 849-869, 21 AA, Helical. {ECO:0000255}.

Sequence: 1044 AA

10 20 30 40 50 60 MVLSLTGLIA FSFLQATLAL NPEDPNVCSH WESYAVTVQE SYAHPFDQIY YTRCTDILNW 70 80 90 100 110 120 FKCTRHRISY KTAYRRGLRT MYRRRSQCCP GYYESGDFCI PLCTEECVHG RCVSPDTCHC 130 140 150 160 170 180 EPGWGGPDCS SGCDSDHWGP HCSNRCQCQN GALCNPITGA CVCAAGFRGW RCEELCAPGT 190 200 210 220 230 240 HGKGCQLPCQ CRHGASCDPR AGECLCAPGY TGVYCEELCP PGSHGAHCEL RCPCQNGGTC 250 260 270 280 290 300 HHITGECACP PGWTGAVCAQ PCPPGTFGQN CSQDCPCHHG GQCDHVTGQC HCTAGYMGDR 310 320 330 340 350 360 CQEECPFGSF GFQCSQHCDC HNGGQCSPTT GACECEPGYK GPRCQERLCP EGLHGPGCTL 370 380 390 400 410 420 PCPCDADNTI SCHPVTGACT CQPGWSGHHC NESCPVGYYG DGCQLPCTCQ NGADCHSITG 430 440 450 460 470 480 GCTCAPGFMG EVCAVSCAAG TYGPNCSSIC SCNNGGTCSP VDGSCTCKEG WQGLDCTLPC 490 500 510 520 530 540 PSGTWGLNCN ESCTCANGAA CSPIDGSCSC TPGWLGDTCE LPCPDGTFGL NCSEHCDCSH 550 560 570 580 590 600 ADGCDPVTGH CCCLAGWTGI RCDSTCPPGR WGPNCSVSCS CENGGSCSPE DGSCECAPGF 610 620 630 640 650 660 RGPLCQRICP PGFYGHGCAQ PCPLCVHSSR PCHHISGICE CLPGFSGALC NQVCAGGYFG 670 680 690 700 710 720 QDCAQLCSCA NNGTCSPIDG SCQCFPGWIG KDCSQACPPG FWGPACFHAC SCHNGASCSA 730 740 750 760 770 780 EDGACHCTPG WTGLFCTQRC PAAFFGKDCG RVCQCQNGAS CDHISGKCTC RTGFTGQHCE 790 800 810 820 830 840 QRCAPGTFGY GCQQLCECMN NSTCDHVTGT CYCSPGFKGI RCDQAALMME ELNPYTKISP 850 860 870 880 890 900 ALGAERHSVG AVTGIMLLLF LIVVLLGLFA WHRRRQKEKG RDLAPRVSYT PAMRMTSTDY 910 920 930 940 950 960 SLSGACGMDR RQNTYIMDKG FKDYMKESVC SSSTCSLNSS ENPYATIKDP PILTCKLPES 970 980 990 1000 1010 1020 SYVEMKSPVH MGSPYTDVPS LSTSNKNIYE VEPTVSVVQE GCGHNSSYIQ NAYDLPRNSH 1030 1040 IPGHYDLLPV RQSPANGPSQ DKQS

CATM prediction

The sequence of MEG11_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      850       860       870
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 RHSVGAVTGIMLLLFLIVVLLGLFAWH 7.2 -30.0° 3.5 53.0 -16.5
Model 2 RHSVGAVTGIMLLLFLIVVLLGLFAWH 6.6 -55.2° 5.6 39.7 -10.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session